I put the Michelin Defender LTX M/S on our 2016 Pilot to replace worn-out stock Contis and they are fine. I can't really tell the difference on-road but the Michelins are a bit more confident in light off-road conditions. The Michelins are supposed to be better in winter, but I have Blizzaks for that. The one issue with the LTXs is that they look a bit more "truckish" because of the blocky edge. Not an issue for me on the Pilot, but I'm not sure if they will pass the wife approval factor for her 2014 MDX, which is getting there on the stock Contis. I stretched them another season by getting dedicated winter tires ( Nokian Hakkapeliittas... awesome winter tires and I just can't stop saying that name ), but that is the quandary. I'm inclined to get the Michelins for that vehicle too, but we'll see.
Another option is Michelin Premier LTX, and I put those on an older MDX in our family fleet, but that one doesn't rack up many miles at this point. Treadwear may be an issue with those tires, from some reports.