[habbyguy]

You just have to do the calculations, based on the width (of the tire) and the offset. There's room above and beyond the standard tires, but you will notice a marked increase in road noise and transmitted vibrations with lower profile tires.

 

[habbyguy]

Here's the best resource to figure out that kind of thing...

Acura MDX - Specs of wheel sizes, tires, PCD, Offset and Rims for all model years

You can look up the wheel sizes / lug patterns / offset / centerbore / width specs for the wheels you're considering, then do the math (and of course, make sure all the other parameters work, like centerbore - one that's often overlooked - lug pattern, etc.).