Sure.
In my 2002 I recently installed a Pioneer AVH-4200NEX in a double-DIN below the OEM screen. This maintains the climate controls (and factory nav, if you have it) while adding Apple CarPlay, HD radio, and multiple input/output options. You can also connect two cameras (I already had a backup camera running through my top screen, but you could hook one up to the Pioneer).
I think the 2-screen set-up looks cool, too.
Original speakers sound fine, especially with mpg4 files.
Sorry I can't figure out how to rotate the thumbnail.