We have a 2500 Denali Crew cab (2015) and a 2019 MDX hybrid advanced. The denali has a noticeably quieter interior, better road noise isolation and less wind noise, The MDX is better than the majority of Honda/Acura vehicles we've ridden in and is quiet enough. Seat comfort they are comparable and the rear seats in the hybrid advance with captains chairs are as comfortable as the rear seats in the denali. The Denali was our long distance cruiser, but now it's the MDX. IMHO the dash and controls for most items like audio, seat heaters, climate control etc. are better on the Denali. MDX requires taking eyes off the road more than the denali which by now I seldom need to do. MDX wins hands down on handling and for MOST snow rain conditions vs. the part time Four Wheel drive. And the MDX has a far better traction control system. Part may be due to the hybrid with complete individual control to the rear wheels.
Denali is now our trailer tow vehicle, big loads etc. MDX our most often driven vehicle. Course the MDX hybrid wins on economy, 26-28 in town, 28 on the highway