Interesting. I was going to recommend the RX350L since it's more akin to the MDX.Our problem car was a 2007 Lexus RX350 that we got rid of and replaced with the 2015 MDX. We intended to keep it until the three row RX was released for 2018 then replace it with one of those. It didn’t make it.
Every brand will build a bad one from time to time.
I traded a 2016 Highlander (same platform/drivetrain as the RX350L) on the MDX. I wish I would have test-driven the RX350L back-to-back with the MDX. My Highlander was absolutely rock solid with nary an issue in the 4 years I owned it (and it had the keyless entry you speak of). Not even so much as a rattle or squeak. I have frequently regretted not going over to the Lexus. That said, I appreciate your take.