One thing that shocked me about the Jeep Grand Cherokee is that it doesn't offer conventional front side airbags. E.g. ones that deploy around your abdomen (thorax).
Chrysler does offer side curtain airbags for the front and rear. While having those are nice, they only protect adult heads in a side impact, usually when the impact is very high (e.g. sliding sideways into a utility post).
While the Jeep gets 4/5 stars for side impacts, it isn't 5/5, and, critically, the NHTSA test uses a relatively low barrier (approximating a small sedan). It's when you get hit by another SUV or minivan when you really want the thoracic side impact airbag, since the forces are going to go against your pelvis and chest.
IIHS is working on a side-impact test with a higher (SUV-height) barrier.
To me, the Grand Cherokee's lack of basic front side impact air bags (more critical than side curtains in an SUV), and its "marginal" IIHS crash test score, are major issues.
http://www.iihs.org/vehicle_ratings/ce/html/99009.htm