How the Honda/Acura MPG calculations work is a mystery to me. It will always show fewer miles than I just completed on the previous tank as a remaining distance, but then the distance will start increasing, but only in fairly large jumps. For example, it might show 333 miles of range when I fill up after driving 360 miles, then show 300 miles after 35 miles of driving, but then show 280 miles after 100 miles of driving. I've been getting 400 miles on the best tanks total (my odometer is pretty accurate, too), with the total remaining plus traveled miles going as high as 450+ miles at times.
That is to say, there's no way in the world I'd keep going past a gas station showing 80 miles remaining if I knew the next gas station was 75 miles away (which is pretty common in the western US).