I just bought 2008 MDX and that was the first thing that I notice - all this dust, so I cleaned it this weekend. It does require some disassemble thought. You have to remove the radio side trim following the instruction posted on this tread (on the pdf):
Dash Removal to access DVD/Radio on 2007 MDX
don't forget to remove the bottom plastic piece between the radio and the mid console trim (it is in the instruction). The next step will be to unscrew the four screws holding the stereo in place (two on each side). Place a tower on the mid console so you don't scratch the trim and gently pull the radio out. Remove the two screws on the side facing down that hold the top display to the radio. Now lift the display and utilizing the flat side of knife gently lift the clips on the bottom and top holding the plastic window. Clean the screen with LDC friendly cleaner and follow the reverse steps to put everything in place. Good Luck
bgkorekom, thanks. I followed these instructions last night, and was able to successfully clean the display (I chickened out last time I had it all apart, and stopped short of removing the radio unit). But it was not difficult.
A couple additions. Aside from the upside-down screws facing down, there is another screw on either side of the display unit holding it in place on the metal frame horizontally (at least on my 2009). I would also caution that the LCD is extremely susceptible to light/hairline scratches. I was using a microfiber cloth, and actually ended up leaving a tiny scratch on the screen. It's not noticeable from 3 feet away with the unit all reinstalled, but the point is, proceed with caution.
After reconnecting the negative battery terminal, I had to re-enter the anti-theft code for both the radio and the nav unit (they have separate codes), so have those handy. Then I had to drive into an open area and wait a few minutes with the engine started to allow the nav system to acquire a GPS satellite fix.
IMO, the hardest part of the whole process is removing the dashboard trim, mostly because, not knowing how strong the retaining tabs and clips are, I moved very slowly to take care not to damage the plastic parts.
I would also caution having a dealer do this, your mileage may vary. They have the right tools to take the radio out easily, sure, but again, the LCD is fairly fragile. You wouldn't want to put yourself in an awkward place where the tech decides to wipe the dust out with an abrasive shop rag or something and ends up making it worse than you started out with. I actually called my dealer about this before proceeding on my own and they told me they don't service the screen-- they basically said if it bothered me that much, I'd have to buy a new unit (a $400+ part).
Good luck, fellow OCDers.